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Genetic Testing for Cancer: Identifying Risks for Cancer Prevention

Cancer is a serious disease caused by the abnormal growth of cells in the body. These cells can spread to different parts of the body, damaging organ function. Early detection and diagnosis of cancer are crucial as they can help prevent the disease, increase the chances of successful treatment, and reduce mortality rates. One of the modern medical technologies for screening and diagnosing cancer risks is genetic testing. This testing identifies genetic abnormalities that may lead to cancer, enabling the development of appropriate prevention and treatment plans. Genetic testing for cancer can thus be considered a significant advancement in the fight against cancer.


What is Genetic Testing for Cancer?

Genetic testing for cancer is a medical technology that analyzes an individual’s genes or DNA to identify changes or abnormalities that may lead to cancer in various organs. This testing aids in diagnosing and assessing the risk of future cancer development and helps formulate personalized treatment plans for cancer patients.


How Are Cancer and Genes Related?


Cancer is a disease resulting from uncontrolled cell growth, which may result from genetic changes or abnormalities. Genes, the basic units of heredity, determine the characteristics and functions of the body’s cells. Genetic changes can arise from various factors, including inheritance or exposure to environmental carcinogens, such as chemicals, radiation, or viruses.


Types of Genetic Changes Linked to Cancer


Genetic changes associated with cancer typically fall into two main categories:


  • Oncogenes: These genes promote normal cell growth and division. However, when mutated, they can lead to uncontrolled cell growth and cancer.
  • Tumor Suppressor Genes: These genes control cell growth and repair damaged DNA. Mutations in these genes can impair their ability to regulate cell growth, increasing the risk of cancer.

Forms of Genetic Changes That Lead to Cancer


Genetic changes that may result in cancer include:


  1. Point Mutations: Single-base changes in DNA sequences can create abnormal proteins, potentially leading to cancer, e.g., mutations in the TP53 gene.
  2. Insertions and Deletions: The addition or removal of bases in DNA sequences can disrupt protein formation, leading to cancer. An example is deletions in the APC gene, which are linked to colon cancer.
  3. Chromosomal Translocations: The exchange of chromosomal segments can create abnormal proteins, e.g., changes in the BCR-ABL gene are associated with leukemia.

Types of Cancer Detectable by Genetic Testing


Currently, genetic testing can screen for the risk of various cancers, such as:


  • Stomach cancer
  • Adrenal gland cancer
  • Prostate cancer
  • Pancreatic cancer
  • Breast cancer
  • Kidney cancer
  • Thyroid cancer
  • Skin cancer
  • Ovarian cancer
  • Endometrial cancer
  • Intestinal cancer
  • Colorectal cancer
  • Other types of cancer

Benefits of Genetic Testing for Cancer


Genetic testing for cancer is increasingly utilized and offers the following key benefits:


  1. Risk Assessment: Helps individuals with a family history of cancer understand their own risks and take preventive measures.
  2. Early Diagnosis: Enables early detection of cancer, increasing the chances of successful treatment.
  3. Personalized Treatment: Guides the development of tailored treatment plans, e.g., using EGFR inhibitors for lung cancer patients with EGFR mutations.
  4. Monitoring Treatment: Helps track treatment outcomes and continuously assess its effectiveness.

Who Should Undergo Genetic Testing for Cancer?


  • Individuals with a Family History of Cancer:

Those with family members affected by specific cancers, such as breast or ovarian cancer, should consider testing for genes like BRCA1 and BRCA2.

  • Cancer Survivors:

Individuals who have previously had cancer are at a higher risk of developing new cancers and may benefit from genetic testing to plan prevention and monitoring.

  • Those with Suspicious Symptoms or Abnormal Test Results:

Genetic testing helps in diagnosing and planning treatment for cases with abnormal findings or symptoms suggestive of cancer.

  • People Seeking Risk Information:

Individuals who want to understand their cancer risks for better health planning.

  • Individuals with Genetic Conditions Linked to Cancer:

Conditions like Lynch syndrome or Li-Fraumeni syndrome can be identified and managed through genetic testing.

  • Proactive Health Planners:

Those aiming to prevent cancer through continuous health monitoring or lifestyle changes.


Advancements in Genetic Testing for Cancer


Advancements in genetic testing, such as Whole Genome Sequencing and Bioinformatics, have significantly improved its efficiency. Additionally, genetic testing can complement emerging treatments like Immunotherapy and Targeted Therapy, improving cancer treatment outcomes.


Conclusion


Genetic testing for cancer is a valuable tool for assessing cancer risk. It is particularly beneficial for individuals with a family history of cancer, cancer survivors, those with suspicious symptoms, or those seeking proactive health strategies. This testing enables personalized health care planning, supporting early detection, prevention, and effective treatment of cancer.

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Calcified Plaque in the Coronary Arteries: The Silent Killer!

Understanding the Causes of Blockage Many people believe that coronary artery disease develops only with age. However, coronary artery problems can begin much earlier in life. The risk starts in youth when fatty deposits (fatty streaks) begin to form in the coronary arteries. Over time, these deposits thicken, eventually leading to artery blockages. Dr. Anupong Parinayok, a cardiologist at Praram 9 Heart and Vascular Institute, explains that the problem begins when the inner lining of blood vessels becomes inflamed and dysfunctional, often due to chronic conditions such as diabetes, high blood pressure, and high cholesterol. Lifestyle factors, such as smoking, also play a significant role. These factors make the blood vessel walls more prone to inflammation, allowing oxidized LDL cholesterol to infiltrate and accumulate within them. Over time, this buildup forms plaques and calcium deposits in the coronary arteries. If these plaques rupture, they can trigger the formation of a blood clot, leading to an acute heart attack. At this stage, quick medical intervention is crucial to prevent life-threatening complications. Ideally, however, it is best to prevent reaching this stage.

Fear of the Sun? It Could Be Putting You at Risk for “Osteoporosis”

When people thinking of Thailand, many picture the sun, and just imaging it can make you want to grab an umbrella. But did you know that sunlight is more important to Thais than you might think? The gentle sunlight of the early morning and late afternoon not only warms the body but also helps produce vitamin D, which is crucial for strengthening bones, reducing the risk of osteoporosis. Many people view sunlight as harmful, causing skin damage, wrinkles, and hyperpigmentation, leading them to overlook its benefits. Studies show that sunlight is essential for preventing osteoporosis and vitamin D deficiency. Exercising under soft sunlight in the morning allows the body to absorb vitamin D, which strengthens bones and reduces the risk of osteoporosis. In Thailand, 2.5-3% of the population of all genders and ages suffer from osteoporosis. Dr. Peeraphong Sawatdipong, an orthopedic surgeon specializing in knee and hip replacements at Praram 9 Hospital, revealed that vitamin D deficiency is highly prevalent in Thailand, affecting 30-40% of patients. The primary cause is an excessive fear of sunlight, leading to fragile bones and a higher risk of fractures, particularly among the elderly and postmenopausal women. In reality, morning sunlight, when absorbed through the skin, significantly helps the body produce vitamin D, which strengthens bones and reduces the risk of osteoporosis later in life.

Why Are Young, Active People Still at Risk for Sudden Cardiac Arrest?

Recently, we’ve often heard of athletes—seemingly healthy and young—suddenly passing away, raising concerns about the true cause of sudden cardiac arrest (SCA) in athletes and young adults. Is there a connection with exercise? And how can we handle such situations to prevent unforeseen tragedies for ourselves and our loved ones? The Real Causes of Sudden Cardiac Arrest Dr. Phonpitchaya Boondee, a cardiologist at the Praram 9 Cardiovascular Institute, explains that the incidence of sudden cardiac arrest tends to increase with age. Among younger people, it occurs at a rate of 1:100,000, which rises to 50:100,000 in middle-aged adults and up to 200:100,000 in those over 80 years old. Additionally, men are more at risk of coronary artery disease than women. In young individuals with no underlying conditions, the primary cause of sudden cardiac arrest are usually electrical disturbances of the heart and hypertrophic cardiomyopathy. These are often genetic heart conditions that may present no prior symptoms, leaving individuals unaware they have heart disease.

Ovarian Cysts: A Hidden Threat Every Woman Should Know

These days, who would have thought that “ovarian cysts” would become a silent danger women need to be aware of? What’s even more concerning is that ovarian cysts often present no clear warning signs. Many women may be unaware that they have an ovarian cyst until they experience severe symptoms such as intense menstrual cramps, irregular periods, abdominal bloating, noticeable lumps in the pelvic area, or severe pain during intercourse. If left untreated, this condition can potentially be life-threatening. Unveiling the Secrets of Ovarian Cysts with a Specialist Professor Emeritus Dr. Sangchai Preutthipan, a specialist in reproductive medicine and laparoscopic surgery from Praram 9 Hospital, explains that the “ovaries” are small, thumb-sized organs responsible for producing eggs each month. With each ovulation, a fluid-filled sac forms around the egg. Sometimes, these sacs don’t dissolve as they should, leading to cyst formation. There are several types of ovarian cysts, including those caused by ovarian dysfunction, tumor-related cysts, endometriosis cysts (also known as chocolate cysts), cysts resembling other body tissues, and even cancerous cysts. Dr. Sangchai further notes that women of reproductive age up until menopause are at risk for ovarian cysts. Around 30-35% of women develop cysts due to ovarian dysfunction, while 20% develop tumor-related or chocolate cysts. Approximately 15% may have cysts that resemble other tissue types, and 1-5% are diagnosed with cancerous cysts. Each type of cyst carries different health risks.

Kidney Transplant Surgery Procedure, Recovery, and Complications to Monitor

Kidney transplantation is a surgical procedure that involves transplanting a kidney from a living donor or a donor who is brain-dead into a patient with chronic kidney failure, without removing the patient’s existing kidneys. The new kidney takes over the function of the damaged kidneys. The success rate of kidney transplantation is relatively high, and after the procedure, patients can experience a significant improvement in their quality of life. Therefore, kidney transplantation is considered the best treatment for chronic kidney failure. However, it is a major surgery with complex procedures. Before the operation, the donor kidney must be carefully matched to the recipient with chronic kidney failure, ensuring compatibility of blood and tissue between the donor and recipient to prevent rejection. Once a suitable kidney is found, the surgeon will perform the transplant on the patient. During and after the surgery, patients may face the risk of serious complications, so they must be closely monitored by a medical team. After the surgery, patients need to recover in the hospital to ensure that the new kidney is functioning properly and effectively.

Protect Yourself from Monkeypox: Know the Signs and Stay Safe

The World Health Organization (WHO) has declared a global health emergency due to a severe outbreak of monkeypox across Africa, where more than 450 deaths have been reported. Previously, in 2022, the WHO declared a public health emergency due to an outbreak of Clade 2, which is known for its milder symptoms. Although Clade 2 spread to over 100 countries, including Europe and Asia, it resulted in more than 87,000 cases and 140 deaths, with a mortality rate of 4%. The outbreak was primarily concentrated among the LGBTQ+ community, which allowed for targeted vaccination efforts to contain it effectively. This time, however, the outbreak involves Clade 1, which is much more severe, with a mortality rate of up to 10%. According to the Africa Centers for Disease Control and Prevention (Africa CDC), more than 14,500 monkeypox cases and over 450 deaths were reported between early 2024 and July, This represents a 160% increase in infections and a 19% increase in deaths compared to the same period in 2023.

How Long Can A Kidney Transplant Recipient Live After Surgery?

The kidneys are vital organs in the body, making kidney disease a significant issue that affects both the patient’s quality of life and the lives of those who care for them. Today, there has been an increase in kidney disease cases compared to the past, with a growing number of patients reaching end-stage chronic kidney failure and requiring urgent treatment. Kidney transplantation is considered the best treatment option for restoring the patient’s quality of life.

Thyroid Disease Symptoms! Which type of thyroid disease do these symptoms indicate?

The thyroid gland is a butterfly-shaped organ located at the front of the neck. Its main function is to produce thyroid hormones, which are crucial for the body’s metabolic system. These hormones also contribute to growth and regulate heart rate, body temperature, and other hormonal functions. When the thyroid gland malfunctions, it can affect the levels of thyroid hormones in the body, leading to conditions like hyperthyroidism (excess thyroid hormone), hypothyroidism (insufficient thyroid hormone), or other thyroid disorders. Patients with these conditions may exhibit different symptoms. This article will explain the symptoms of various types of thyroid diseases to help you recognize them early. If you suspect any issues, it’s important to consult a doctor for prompt diagnosis and treatment.

Cardiac Arrhythmia : A warning sign that may lead to heart failure

The heart is an essential organ that works tirelessly all the time. On average, the heart beats around 100,000 times a day. Nowadays, heart disease is becoming increasingly common and close to us. We often hear news of people we know, or those close to us, passing away due to heart disease, or instances of athletes collapsing during competitions caused by irregular heartbeats. Cardiac arrhythmia is considered a type of heart disease that is frequently mentioned today. An irregular heartbeat causes abnormal heart contractions. If severe and left untreated, it can lead to heart failure. Therefore, taking care of heart health is extremely important and should not be neglected.

Gynecologic Laparoscopic Surgery: A Great Option for Women

When it comes to women’s surgeries, besides the anxiety about the results, the pain from the surgery and the scars afterward are other significant concerns. Nowadays, medical advancements have provided women with treatment options that yield good results while leaving only small scars. The pain from the surgical wound is minimal, recovery is quick, and there are no severe complications. One such option is gynecologic laparoscopic surgery.

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